ImmunologybioRxivPreprint
Cullin1 represses systematic inflammasome activation by binding and catalyzing NLRP3 ubiquitination
Pin Wan, Qi Zhang, Weiyong Liu…·Jianguo Wu
This study identifies CUL1 as a repressor of NLRP3 inflammasome activation by ubiquitinating NLRP3, showing its role in controlling immune responses under physiological and inflammatory conditions.