Considerations for the use of contrast agents with diffuse in vivo flow cytometry to detect circulating cancer cell populations
Joshua Pace, Grace Matheson, Gauri S. Malankar, Lei Wang, Melissa Hirose Wong, Summer L. Gibbs, Mark J. Niedre
This paper evaluates contrast agents for in vivo fluorescence detection of circulating tumor cells, finding that while they show high uptake, they also label non-cancer cells, reducing specificity.
bioRxiv · Jul 28, 2025 · PreprintBioengineering