BiophysicsbioRxivPreprint
Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E
Agnese Roscioni, Vincenzo Maria D’Amore, Jesmina Rexha…·Francesco Saverio Di Leva
This study investigates how two structurally similar ligands, 4EGI-1 and i4EG-BiP, regulate eIF4E through distinct binding modes, revealing that frontal binding promotes 4E-BP1 over eIF4G interaction.
DOI 10.64898/2025.12.23.696204