Author

Guang Li

Hunan Provincial Maternal and Child Health Hospital

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Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Evolutionary Biology· 1 Genetic & Genomic Medicine· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A W XuiD· 1 shared Aaron Demers· 1 shared Aaron M. Kershner· 1 shared Ahmad N. Nabhan· 1 shared Albin Huang· 1 shared Andrew P. May· 1 shared Angela Pisco· 1 shared Ankit S. Baghel· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperEvolutionary Biology

A W XuORCID

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Author profile →

5 papers

Recent·Most cited

Tracing the Evolutionary Origin of Interferon to Basal Chordates and Unveiling Its Antiviral Functionality in Jawless Vertebrates

Xinli Wang, Qinghuan Wang, Anni Xie, Lisi Deng, Ziwen Huang, Y ZHAO, Yange Cao, Rong Fu, Weicong Huo, Yuehua Chen, Guang Li, A W Xu, Shaochun Yuan

This study identifies IFN homologs in jawless vertebrates and demonstrates their antiviral function, tracing the evolutionary origin of IFN to basal chordates.

bioRxiv · Jun 3, 2026 · PreprintEvolutionary Biology

Single-cell Landscape of T Cell Heterogeneity in Kawasaki Disease: STAT3/JAK Axis Regulates the Lineage Differentiation Bias of Th17 Cells

Sirui Song, Yanfang Zong, Yanbing Xu, Liqin Chen, Y P Zhou, Le Chen, Guang Li, Tingting Xiao, Min Huang

The paper uses scRNA-seq to analyze T-cell subtypes in Kawasaki disease, identifying a Th17 differentiation bias regulated by the STAT3/JAK axis during acute inflammation.

bioRxiv · Mar 23, 2026 · PreprintBioinformatics

Impact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolites Composition

Youyou Huang, Jiao Wan, Chuqiang Shu, Xichun Yan, Jingyue Ma, Tian Zhang, Jiarong He, Ziqing Wan, Guang Li, Qi Zhang, Zengzi Zhou, Xin Sun, Jing Zhao, Pu Zhang, Luying Wang, , Qi Tian

This study examines the effects of oral Chlamydia vaccination on gut microbiome and metabolite composition, identifying microbial and metabolic changes and potential biomarkers of immunization.

mSystems · Nov 10, 2025Peer-reviewedMicrobiology

Whole-Genome Sequencing is a Viable Replacement for Chromosomal Microarray and Fragile X PCR Testing

Yueyao Gao, Sarah T. South, Colyn B. Cargile, Julie L Cox, Mark Fleharty, Benjamin Hilton, Katie L. Larkin, Guang Li, David W Marsh, Victoria Popic, Reha M. Toydemir, Sean E. Hofherr, Niall J. Lennon, Peter H Bui

This study shows that whole-genome sequencing can replace chromosomal microarray and Fragile X testing with higher accuracy and broader coverage for genetic disorders.

medRxiv · May 24, 2025 · PreprintGenetic & Genomic Medicine

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

Nicholas Schaum, Jim Karkanias, Norma F Neff, Andrew P. May, Stephen R. Quake, Tony Wyss-Coray, Spyros Darmanis, Joshua Batson, Olga Botvinnik, Michelle B. Chen, Steven Chen, Foad Green, Robert Jones, Ashley Maynard, Lolita Penland, , Tony Wyss-Coray

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.

bioRxiv · Mar 29, 2018 · PreprintCell Biology