Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination
Zara Bukhari, Li Gu, Anneroos E Nederstigt, Logan J. Cope, Derek L. Bolhuis, Kim Harvey, Tristan Allen, Spencer Hill, Yujie Yang, Guy Lawson, Lu Cai, Tommy Tran, Leah Pineda, Leanne M. Low, Andrew H. Chiang, , Joseph S. Harrison
This paper designs a protein inhibitor for UBE2D enzymes to study their role in ubiquitination, showing it reduces Ub degradation and proteotoxic stress in HeLa cells.
Cell chemical biology · Dec 1, 2025Peer-reviewedBiochemistry