BiochemistryCell chemical biologyPeer-reviewed
Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination
Zara Bukhari, Li Gu, Anneroos E Nederstigt…·Joseph S. Harrison
This paper designs a protein inhibitor for UBE2D enzymes to study their role in ubiquitination, showing it reduces Ub degradation and proteotoxic stress in HeLa cells.
DOI 10.1016/j.chembiol.2025.11.007