Author

H. Arakawa

The University of Tokyo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1

Frequent Co-Authors

N. Ikari· 2 shared Akihiro IshiwataiD· 1 shared Chih-Chieh LiniD· 1 shared H. Higashida· 1 shared H. Morishita· 1 shared Hana NamikiiD· 1 shared I. Tamai· 1 shared K. Honjo· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

N. Ikari

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Author profile →

5 papers

Recent·Most cited

Neutron crystallography of the covalent intermediate of β-glucosidase reveals remodeling of the catalytic center

Naomine Yano, Toma Kashima, H. Arakawa, Chih-Chieh Lin, Akihiro Ishiwata, Hana Namiki, Naoki Takaya, Katsunori Tanaka, Katsuhiro Kusaka, Shinya Fushinobu

This paper uses neutron crystallography to determine the structure of β-glucosidase Td2F2 in different ligand states, revealing hydrogen bonding networks and structural changes in the catalytic center during covalent intermediate formation.

Proceedings of the National Academy of Sciences · Oct 30, 2025Peer-reviewedBiochemistry

Functional identification of soluble uric acid as an endogenous inhibitor of CD38

S. Wen, H. Arakawa, S. Yokoyama, Y. Shirasaka, H. Higashida, I. Tamai

This study identifies soluble uric acid as an endogenous inhibitor of CD38, showing it limits NAD+ degradation and suppresses inflammation in mice.

bioRxiv · Jun 3, 2023Immunology

Identification of a mitochondrial targeting sequence in cathepsin D and its localization in mitochondria

N. Ikari, H. Arakawa

The paper identifies a mitochondrial targeting sequence in cathepsin D and shows its localization in mitochondria through live-cell imaging and biochemical assays.

bioRxiv · Jan 23, 2023Cell Biology

Mieap forms membraneless organelles to compartmentalize and facilitate cardiolipin metabolism

N. Ikari, K. Honjo, Y. Sagami, Y. Nakamura, H. Arakawa

The paper shows Mieap forms membraneless organelles to compartmentalize and facilitate cardiolipin metabolism, supporting mitochondrial quality control.

bioRxiv · Oct 26, 2020Cell Biology

Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein

H. Morishita, K. Okawa, M. Ishii, K. Mizoi, H. Arakawa, K. Yano, T. Ogihara

The paper investigates drug-drug interactions between pimozide, sertraline, and aripiprazole, showing that the latter two inhibit P-glycoprotein, increasing pimozide absorption and potentially causing QT prolongation.

bioRxiv · Apr 16, 2020Pharmacology & Toxicology