M. Ishii

Advancing microbial isolation: The impact of leaf mold extract agar on soil samples

This study develops a leaf mold extract agar medium that enhances the isolation of soil microbes not typically cultured in standard media, including an unidentified species.

Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence

This study identifies Cdc42 and Rac GTPase inhibition as a strategy to block hyphal elongation and virulence in Trichophyton rubrum, with EHop-016 showing promise as an antifungal lead.

An unconventional regulatory circuitry involving Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes

This study shows that Aurora B and KKT14 form an unconventional regulatory pathway controlling mitotic exit and chromosome segregation in trypanosomes.

Kinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins

This study identifies KKT14-KKT15 in kinetoplastids as divergent orthologs of Bub1/BubR1-Bub3, suggesting a unique mechanism for chromosome segregation fidelity in trypanosomes.

The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum

This study identifies the TrPtk2-TrPma1 pathway in Trichophyton rubrum as critical for terbinafine tolerance and suggests it as a target for antifungal therapy.

2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

This study identifies 2-thiouridine as a broad-spectrum antiviral against SARS-CoV-2 and other positive-strand RNA viruses by inhibiting viral RNA synthesis.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

Divergent polo boxes in KKT2 and KKT3 initiate the kinetochore assembly cascade in Trypanosoma brucei

This study identifies KKT2 and KKT3 as kinetoplastid kinetochore proteins that use divergent polo boxes to recruit downstream proteins, essential for kinetochore assembly in Trypanosoma brucei.

Targeted protein degradation using degradFP in Trypanosoma brucei

This paper adapts degradFP, a protein degradation system, to Trypanosoma brucei to enable targeted protein depletion, demonstrating its effectiveness on both nuclear and cytoplasmic proteins.

Environmental filtering in marine fish communities is weakened during severe hypoxia season

This study shows that environmental filtering in marine fish communities weakens during severe hypoxia, despite increased environmental severity and heterogeneity.

Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein

The paper investigates drug-drug interactions between pimozide, sertraline, and aripiprazole, showing that the latter two inhibit P-glycoprotein, increasing pimozide absorption and potentially causing QT prolongation.

Unconventional kinetochore kinases KKT2 and KKT3 have unique centromere localization domains

This study identifies unique central domains in KKT2 and KKT3 kinases that mediate centromere localization in Trypanosoma brucei.

Unconventional kinetochore kinases KKT10/19 promote the metaphase to anaphase transition in Trypanosoma brucei

This study identifies KKT10/19 as kinetochore kinases essential for the metaphase to anaphase transition in Trypanosoma brucei, revealing their role in phosphorylation and localization regulation.