Author

S. Wen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 2 Bioengineering· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

B. Psaila· 2 shared J. O'Sullivan· 2 shared S. Thongjuea· 2 shared Y. Liu· 2 shared A. Adamo· 1 shared A. Cotton· 1 shared A. Enshaei· 1 shared A. Hamblin· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

B. Psaila

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Hexose transporters CsHT3/16 involved in post-phloem transport and affected cucumber fruit development

J. Cheng, S. Wen, K. Li, Y. Zhou, M. Zhu, H. E. Neuhaus, Z. Bie

The paper identifies CsHT3/16 as key hexose transporters in cucumber fruit development, showing their role in sugar homeostasis and fruit size regulation through expression patterns and mutant analysis.

bioRxiv · Jan 25, 2024 · PreprintPhysiology

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

R. Li, M. Colombo, G. Wang, A. Rodriguez-Romera, J. O'Sullivan, S.-A. Clark, J. Perez Saez, Y. Meng, A. Khan, S. Wen, P. Dong, W. Zhou, N. Sousos, L. Murphy, M. Clarke, , B. Psaila

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

bioRxiv · Aug 5, 2023 · PreprintCancer Biology

Functional identification of soluble uric acid as an endogenous inhibitor of CD38

S. Wen, H. Arakawa, S. Yokoyama, Y. Shirasaka, H. Higashida, I. Tamai

This study identifies soluble uric acid as an endogenous inhibitor of CD38, showing it limits NAD+ degradation and suppresses inflammation in mice.

bioRxiv · Jun 3, 2023Immunology

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

X. Ming, Y. Sun, X. Zhou, Y. Qin, L. Yang, S. Wen, Y. Qiu, T. Jin, S. Chen, R. Tang, Y. Guo, L. Mranran

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

bioRxiv · Apr 28, 2023 · PreprintCancer Biology

Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns

M. A. Rossotti, H. van Faassen, A. Tran, J. Sheff, J. A. Sandhu, D. Duque, M. Hewitt, S. Wen, R. Bavananthasivam, S. Beitari, K. Matte, G. Laroche, P. M. Giguere, C. Gervais, M. Stuible, , J. Tanha

This paper presents a diverse set of nanobodies targeting SARS-CoV-2 spike glycoprotein with broad neutralization activity against multiple variants and high in vivo efficacy.

bioRxiv · Dec 20, 2021 · PreprintBioengineering

In Vitro efficacy comparison of linezolid, tedizolid, sutezolid and delpazolid against rapid growing Mycobacteria isolated in Beijing, China

S. Wen, X. Gao, W. Zhao, F. Huo, G. Jiang, L. Dong, L. Zhao, F. Wang, X. Yu, H. Huang

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

International Journal of Infectious Diseases · Aug 1, 2021Peer-reviewedMicrobiology

MicroRNA-224 Promotes Cell Migration and Invasion by Targeting HOXA5 expression in Hepatocellular Carcinoma

Y. Liu, C. Lin, D. Wang, S. Wen, J. Wang, Z. Chen, J. Du, C. Ning, D. Feng

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

bioRxiv · Aug 27, 2020 · PreprintCancer Biology

Alteration of Gut Microbiome in Lung Cancer Patients

M. Li, F. Yu, X. Chen, H. Zhou, X. Wei, Y. Liu, Y. Liu, L. Tang, S. Wen, J. Yuan, J. Chen

This study examines gut microbiome differences between lung cancer patients and healthy individuals, finding altered microbial composition but unclear links to cancer development.

bioRxiv · May 16, 2019 · PreprintMicrobiology