Targeting cardiac myocyte Na+ pump function with β3 adrenergic agonist in rabbits and patients with severe congestive heart failure
N. A. S. Fry, C.-C. Liu, A. Garcia, E. J. Hamilton, K. Karimi Galougahi, Y. J. Kim, J. L. Harris, G. I. C. Nelson, D. W. Whalley, H. Bundgaard, H. H. Rasmussen
This study shows that β3 adrenergic agonists improve cardiac function in rabbits and patients with severe heart failure by enhancing Na+-K+ pump activity and reducing congestion.
bioRxiv · Dec 6, 2019 · PreprintPhysiology