A. Garcia

Contribution of telacebec to novel drug regimens in a murine tuberculosis model

This study evaluates telacebec's contribution to combination therapies against two M. tuberculosis strains in a murine model, finding synergistic effects against HN878 and antagonistic effects against H37Rv.

In-vitro resensitization of multidrug resistant clinical isolates of Enterococcus faecium and faecalis through phage-antibiotic synergy

This study investigates synergistic interactions between phages and antibiotics in Enterococcus isolates, finding that phage-antibiotic combinations can eradicate vancomycin-resistant strains.

Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice

This study evaluates two compounds that reduce triglyceride content in Mtb-infected macrophages but finds they do not reduce bacterial burden or inflammation in infected mice.

The Origins of ATP Dependence in Biological Nitrogen Fixation

This study experimentally reconstructs an ancestral nitrogenase enzyme and shows it strictly requires ATP hydrolysis for N2 reduction, decoupling cofactor selection from environmental availability.

Dietary tryptophan and genetic susceptibility expand gut microbiota that promote systemic autoimmune activation

The paper shows that dietary tryptophan and genetic factors shape gut microbiota, which in turn influence autoimmune activation in lupus.

RNA virus-mediated gene editing for tomato trait breeding

This paper demonstrates the use of virus-induced genome editing (VIGE) in tomato to edit genes related to fruit color and achieve heritable trait modifications.

A simple solid media assay for detection of synergy between bacteriophages and antibiotics

The paper develops a solid media assay to assess synergistic interactions between antibiotics and bacteriophages, identifying synergistic effects across diverse bacterial isolates.

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

Jumbo phages are active against extensively-drug-resistant eyedrop-associated Pseudomonas aeruginosa infections.

The paper identifies jumbo and non-jumbo phages effective against XDR Pseudomonas aeruginosa isolates causing eyedrop-associated infections.

Integrating Biotic Interactions In Niche Analyses Unravels Patterns Of Community Composition in Clownfishes

This study integrates biotic interactions into niche modeling to reveal how mutualistic relationships influence clownfish community composition and diversity.

Long-term fertilization modifies the composition of slow-growing oligotrophs more than fast-growing copiotrophs in a nutrient poor coastal plain wetland

This study shows long-term fertilization reduces oligotrophic bacteria in wetland soils, potentially decreasing carbon storage capacity.

ISCB RSG-Spain and highlights from the VIII Spanish Student Symposium in Bioinformatics and Computational Biology in 2021

The paper introduces RSG-Spain, an ISCB regional student group, and highlights the VIII Spanish Student Symposium in Bioinformatics and Computational Biology, discussing its organization and challenges.

Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes

This study compares the toxicity of Mn3O4 nanoparticles and their precursor material across different in vitro models representing alveolar, oral, and dermal exposure routes.

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

The paper identifies a genetic mechanism in Fulani individuals that enhances splenic clearance of rigid erythrocytes, contributing to splenomegaly and partial malaria resistance.

Duplication and overexpression of the genes encoding a beta 1,3-glucan synthase confer the intrinsic resistance to echinocandin in Mucor circinelloides

This study identifies gene duplication and calcineurin-mediated overexpression of fks genes as mechanisms of intrinsic echinocandin resistance in Mucor circinelloides.

Novel regimens of bedaquiline-pyrazinamide combined with moxifloxacin, rifabutin, delamanid and/or OPC-167832 in murine tuberculosis models

This paper tests novel tuberculosis treatment regimens in mice, finding that BZM-based regimens show improved sterilizing activity compared to standard care.

An innovative approach to using an intensive field course to build scientific and professional skills

This paper describes a field course that develops scientific and professional skills through iterative project-based learning and evaluation.

LILRB1 and LILRB2 expression in peripheral blood immune cells at 18 and 24 months of age in infants born from mothers with placental malaria

This study examines LILRB1 and LILRB2 expression in immune cells of infants born to mothers with placental malaria, finding lower non-classical monocytes and higher LILRB2 expression associated with increased malaria susceptibility.

Combining Plasma Extracellular Vesicle Let-7b-5p, miR-184 and Circulating miR-22-3p Levels for NSCLC Diagnosis and Drug Resistance Prediction

This study identifies a miRNA biomarker signature combining plasma extracellular vesicle and circulating miRNAs to improve NSCLC diagnosis and predict resistance to Osimertinib.

Quantitation of human enteric viruses as alternative indicators of fecal pollution to evaluate wastewater treatment processes

The paper quantifies human enteric viruses in wastewater samples to assess their potential as indicators of fecal pollution and evaluates their reduction across treatment stages.

Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization

This study shows that CD1c+ dendritic cells can transmit BKPyV to epithelial cells and protect the virus from neutralization.

Targeting cardiac myocyte Na+ pump function with β3 adrenergic agonist in rabbits and patients with severe congestive heart failure

This study shows that β3 adrenergic agonists improve cardiac function in rabbits and patients with severe heart failure by enhancing Na+-K+ pump activity and reducing congestion.

Why Montane Anolis Lizards Are Moving Downhill While Puerto Rico Warms

The paper shows that montane Anolis lizards in Puerto Rico have moved downhill due to forest regeneration, not climate warming, as forests cooled lowland areas more than the warming climate.

A Nanoemulsion as an Effective Treatment Against Human Pathogenic Fungi

This study demonstrates that the nanoemulsion NB-201 effectively inhibits growth of multiple human pathogenic fungi and reduces infection burden in a mouse model.

Muscle MACF1 maintains myonuclei and mitochondria localization through microtubules to control muscle functionalities

This study identifies MACF1 as a regulator of myonuclei and mitochondria positioning in muscle through microtubules, affecting muscle function and disease.