KSR1-and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition
C. Rao, D. E. Frodyma, S. Southekal, R. A. Svoboda, A. R. Black, C. Guda, T. Mizutani, H. Clever, K. R. Johnson, K. W. Fisher, R. E. Lewis
This study shows KSR1 and ERK promote EMT by selectively translating EPSTI1, which facilitates the E-to N-cadherin switch and enhances migration and invasion in CRC cells.
bioRxiv · Jan 18, 2021Cancer Biology