Author

D. E. Frodyma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

K. W. Fisher· 3 shared R. A. Svoboda· 3 shared R. E. Lewis· 3 shared C. Rao· 2 shared A. R. Black· 1 shared A. S. Ireland· 1 shared C. Guda· 1 shared D. Chatterjee· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

K. W. Fisher

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3 papers

Recent·Most cited

PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2

D. E. Frodyma, T. C. Troia, J. A. Berg, C. Rao, R. A. Svoboda, D. D. Shinde, V. C. Thomas, R. E. Lewis, K. W. Fisher

This study identifies PCK2 as a target of PGC-1β and ERRα that promotes glutamine metabolism and colorectal cancer survival through transcriptional regulation.

bioRxiv · May 20, 2022 · PreprintCancer Biology

KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

D. H. Huisman, D. Chatterjee, R. A. Svoboda, H. M. Vieira, A. S. Ireland, S. Skupa, J. W. Askew, D. E. Frodyma, L. Girard, K. W. Fisher, M. Kareta, J. Minna, T. G. Oliver, R. E. Lewis

This study shows KSR2 promotes self-renewal and clonogenicity in ASCL1-subtype SCLC by enhancing ERK signaling and tumor initiating capacity.

bioRxiv · Feb 11, 2022Cancer Biology

KSR1-and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition

C. Rao, D. E. Frodyma, S. Southekal, R. A. Svoboda, A. R. Black, C. Guda, T. Mizutani, H. Clever, K. R. Johnson, K. W. Fisher, R. E. Lewis

This study shows KSR1 and ERK promote EMT by selectively translating EPSTI1, which facilitates the E-to N-cadherin switch and enhances migration and invasion in CRC cells.

bioRxiv · Jan 18, 2021Cancer Biology