C. Rao

KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance

This study identifies KSR1 as a critical regulator of SCLC tumor initiation and cisplatin resistance, showing that its disruption enhances cisplatin toxicity and reduces tumor-initiating cells.

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

This study shows that targeting SOS1 or KSR1 enhances MEK inhibitor efficacy and prevents resistance in KRAS-mutated cancers, depending on specific KRAS and co-mutation status.

PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2

This study identifies PCK2 as a target of PGC-1β and ERRα that promotes glutamine metabolism and colorectal cancer survival through transcriptional regulation.

Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cells

The paper shows that KSR1-dependent signaling in CRC cells promotes SRSF9-mediated splicing of EPSTI1 mRNA, which drives EMT and metastasis.

Regulation of translation by lysine acetylation in Escherichia coli

This study shows lysine acetylation in E. coli inhibits translation by disrupting ribosome subunit association, linking metabolic state to protein synthesis.

Characterization of opposing responses to phenol by Bacillus subtilis chemoreceptors

This study identifies McpA and McpC/HemAT as chemoreceptors for phenol in B. subtilis, showing that phenol is sensed as an attractant and repellent through different domains of McpA.

KSR1-and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition

This study shows KSR1 and ERK promote EMT by selectively translating EPSTI1, which facilitates the E-to N-cadherin switch and enhances migration and invasion in CRC cells.

The unconventional cytoplasmic sensing mechanism for ethanol chemotaxis in Bacillus subtilis

This paper identifies an unconventional ethanol sensing mechanism in Bacillus subtilis where ethanol binds the cytoplasmic signaling domain of McpB and the myoglobin-like sensing domain of HemAT.

Multi-kingdom quantitation reveals distinct ecological drivers of predictable early-life microbiome assembly

The paper quantifies multi-kingdom microbial dynamics in preterm infants and identifies microbe-microbe interactions driving predictable microbiome assembly.

Two tandem mechanisms control bimodal expression of the flagellar genes in Salmonella enterica

The paper identifies two distinct mechanisms controlling bimodal flagellar gene expression in Salmonella enterica, one involving a feedback loop and the other a developmental checkpoint.

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

The paper develops a proteomic atlas of senescence-associated secretomes to identify aging biomarkers, finding that GDF15, STC1, and SERPINs correlate with age in human plasma.

Four chemoreceptors govern bidirectional pH taxis in Bacillus subtilis

This paper identifies four chemoreceptors in Bacillus subtilis that mediate bidirectional pH taxis, with specific residues determining acid or base sensing.

Global lysine acetylation in Escherichia coli results from growth conditions that favor acetate fermentation

This study shows that lysine acetylation in E. coli is primarily influenced by sugar concentration rather than the type of sugar, with higher concentrations leading to more acetylation.

Priming In A Permissive Type I-C CRISPR-Cas System Reveals Distinct Dynamics Of Spacer Acquisition And Loss

This study examines primed adaptation in a type I-C CRISPR-Cas system of Legionella pneumophila, revealing dynamics of spacer acquisition, loss, and sequence constraints.