Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
A. Henssen, C. Reed, E. Jiang, H. D. Garcia, J. von Stebut, I. MacArthur, P. Hundsdoerfer, J. Hyun Kim, E. de Stanchina, Y. Kuwahara, H. Hosoi, N. Ganem, F. Dela Cruz, A. Kung, J. Schulte, , A. Kentsis
This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.
bioRxiv · Aug 25, 2017Cancer Biology