Cancer BiologybioRxiv
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
A. Henssen, C. Reed, E. Jiang…·A. Kentsis
This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.
DOI 10.1126/scitranslmed.aam9078