Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation
K. Duerholz, M. Linnerbauer, E. Schmid, H. Danzer, L. Loesslein, L. Amend, L. Ehnes, M. Frech, V. Azizov, F. Schaelter, A. Gessner, S. Lucas, T.-R. Lesker, R. V. Taudte, J. Hofmann, , M. M. Zaiss
The paper identifies gut microbiota-derived histamine as a factor enabling the CNS to suppress peripheral inflammation in RA by activating H3R in the intestine and modulating microglia.
bioRxiv · Jul 11, 2024 · PreprintImmunology