Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
L. Spiga, R. T. Fansler, Y. R. Perera, N. G. Shealy, M. J. Munneke, T. P. Torres, H. David, A. Lemoff, X. Ran, K. L. Richardson, N. Pudlo, E. C. Martens, Z. J. Yang, E. P. Skaar, M. X. Byndloss, , W. Zhu
This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.
bioRxiv · Jun 25, 2023 · PreprintMicrobiology