A. Lemoff

ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

VCP increases or decreases tau seeding using specific cofactors

This study investigates how VCP and its cofactors influence tau seeding efficiency in cellular models, finding that VCP modulates this process through distinct cofactors.

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.

Insulin receptor substrate 4 deficiency mediates the insulin effect on the epithelial magnesium channel TRPM6 and causes hypomagnesemia

This paper identifies IRS4 as a novel regulator of TRPM6 channel activity and Mg2+ homeostasis, showing IRS4 mediates insulin's effect on TRPM6 phosphorylation and Mg2+ absorption.

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.