H. Dwivedi

Crystal structure of β-arrestin 2 in complex with an atypical chemokine receptor phosphopeptide reveals an alternative active conformation

The paper presents a crystal structure of β-arrestin 2 bound to a phosphopeptide from ACKR3, revealing an alternative active conformation distinct from β-arrestin 1.

Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes

This study uses genetically encoded intrabody sensors to reveal structural and functional diversity in GPCR-β-arrestin complexes, showing distinct functional outcomes across different receptors.

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1

This study investigates ligand bias at C5aR1 by comparing C5a and C5apep, showing differential activation of G proteins, βarr recruitment, endocytosis, and ERK1/2 phosphorylation.