M. Chaturvedi

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.