P. Kumari

Transcriptional reactivation of the tRNASer/tRNATyr gene cluster in Arabidopsis thaliana root tip (V2)

The paper identifies the tissular expression pattern of the SYY tRNA gene cluster in Arabidopsis thaliana root tips and shows its transcriptional reactivation despite DNA methylation.

Structure of the human Duffy antigen receptor

This study determines the cryo-EM structure of the Duffy antigen receptor bound to CCL7, revealing structural features that explain its unique functional properties and lack of G protein coupling.

Supramolecular catch-and-release strategy for bioorthogonal fluorogenic imaging across the visible spectrum

This paper introduces a supramolecular catch-and-release strategy for bioorthogonal fluorogenic imaging using cucurbit[7]uril, enabling efficient and generalizable fluorogenic responses from diverse fluorophores without structural modifications.

Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging

This study uses single-cell RNA sequencing to analyze aging-related changes in the ascending thoracic aorta, revealing mechanosensing and mechanoadaptation alterations linked to immune and vascular changes.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

Commensal fungi Candida albicans modulates dietary high-fat induced alterations in metabolism, immunity, and gut microbiota

This study shows that dietary Candida albicans modulates gut microbiota, metabolism, and immunity, preventing high-fat diet-induced weight gain and inflammation in mice.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

Atomic resolution Protein Allostery from the multi-state Structure of a PDZ Domain

The paper determines multi-state structures of the PDZ2 domain using NMR to study protein allostery and conformational changes.

SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

Temporal resolution of melanogenesis determine fatty acid metabolism as key skin pigment regulator

The paper identifies fatty acid metabolism as a key regulator of melanogenesis by analyzing temporal metabolic and transcriptional changes in melanocytes.

Innate Immune sensing of Influenza A viral RNA through IFI16 promotes pyroptotic cell death

This study shows that IFI16 senses Influenza A viral RNA, activates interferons and cytokines, and promotes pyroptotic cell death during infection.

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

This study shows that auranofin inhibits SARS-CoV-2 replication and reduces inflammation in human cells, suggesting its potential as a therapeutic option for COVID-19.

Recombination in Sarbecovirus lineage and mutations/insertions in spike protein linked to the emergence and adaptation of SARS-CoV-2

This study investigates the origin and adaptation of SARS-CoV-2 through recombination events and mutations in the spike protein, linking these factors to its emergence in humans.

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility

The paper identifies HaRxL21, an oomycete effector, and shows it interacts with TPL to suppress plant immunity and promote pathogen susceptibility.

Human DND1-RRM2 forms a non-canonical domain-swapped dimer

This paper reports the crystal structure of the human DND1 RRM2 domain, revealing a non-canonical domain-swapped dimer formed through a hinge loop and disulfide bonds, with implications for protein interactions and redox regulation.

Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes

This study uses genetically encoded intrabody sensors to reveal structural and functional diversity in GPCR-β-arrestin complexes, showing distinct functional outcomes across different receptors.

The impact of distillery effluent irrigation on plant-growth-promoting traits and taxonomic composition of bacterial communities in agricultural soil

This study examines how distillery effluent irrigation affects bacterial PGP traits and taxonomic composition in agricultural soil, finding no severe impact on these factors.

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1

This study investigates ligand bias at C5aR1 by comparing C5a and C5apep, showing differential activation of G proteins, βarr recruitment, endocytosis, and ERK1/2 phosphorylation.

Microtubule-associated protein IQ67 DOMAIN5 regulates interdigitation of leaf pavement cells in Arabidopsis thaliana

This study identifies IQD5 as a microtubule-associated protein regulating pavement cell shape in Arabidopsis by linking calcium signaling to interdigitation and asymmetric expansion.