Modelling human haematopoietic stem cell commitment ex vivo identifies IL-33 as a regulator of megakaryopoiesis
Emily F. Calderbank, Hugo P. Bastos, Laura Magnani, H. Foster, Kendig Sham, Chenyan Wu, Giovanna Mantica, Carys S. Johnson, Nicole Mende, Daniel Hayler, Stefano Marra, Joakim S. Dahlin, Cédric Ghevaert, Elisa Laurenti
The paper introduces an EPD assay to study human HSC lineage commitment and identifies IL-33 as a regulator of megakaryopoiesis by activating the MAPK pathway.
bioRxiv · Sep 3, 2026 · PreprintCell Biology