C. Huang

Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

This study examines the evolution of the resistome in Salmonella Gallinarum during its transition to endemicity, revealing localized mobilome-driven resistance profiles.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Unraveling factors responsible for pathogenic differences in Lassa virus strains

This study identifies the L protein as a key determinant of pathogenicity in Lassa virus LF2384 compared to LF2350 in guinea pigs through immunological gene profiling and reverse genetics.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.

Directed evolution for cell separation in natural isolates of budding yeast reveals selection to deactivate AMN1 and the Rim101 pathway in haploids and selection in favor of Hawthorne's deletion in diploids

The paper evolves natural yeast isolates to select for cell separation, identifying AMN1 deactivation and Rim101 pathway mutations in haploids, and Hawthorne's deletion in diploids as key adaptations.

Cyclocarya paliurus polysaccharides improve high fat diet-fed mice lipid dysmetabolism through gut microbiota

This study shows Cyclocarya paliurus polysaccharides reduce obesity and lipid dysmetabolism in high fat diet-fed mice by modulating gut microbiota.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling

This study shows that prolactin receptor signaling protects beta-cells from metabolic stress by maintaining incretin receptor expression and insulin secretion.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

UDP-glucosyltransferase 71C4 regulates seed development by redistributing phenylpropanoid metabolism in cotton

This study identifies UGT71C4's role in regulating seed development and yield traits in cotton by modulating phenylpropanoid metabolism, lignin, and flavonoid pathways.

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

The paper identifies lipoavitides, a novel class of RiPP/fatty acid hybrid lipopeptides with a unique HMP modification, and describes their biosynthetic pathway.

Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

This study identifies S1PR4 as a key immune modulator linked to better prognosis in HNSCC through machine learning-based subtype classification and functional analysis.

Exploiting Substrate Specificities of 6-O-Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides

This paper uses sulfotransferase substrate specificities to enzymatically synthesize keratan sulfate oligosaccharides and investigates their binding properties with lectins and viral proteins.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Seed size control via phloem end by callose deposition/degradation of β-1,3-glucanase

The paper identifies a mechanism for seed size regulation through callose deposition/degradation at the phloem end of the ovule, mediated by β-1,3-glucanase genes.

Exogenous Methylglyoxal Improves Maize Yield by Alleviating Plant Diabetes and leaf senescence under Drought

This study shows exogenous methylglyoxal alleviates drought-induced leaf senescence and yield loss in maize by improving sugar metabolism and activating defense pathways.

Reprogramming human B cells with custom heavy chain antibodies

This paper describes a genome editing strategy to reprogram human B cells to express custom heavy chain antibodies that respond to immunization.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Three-dimensional Shear Wave Elastography Using Acoustic Radiation Force and A 2-D Row-Column Addressing (RCA) Array

This paper introduces a 3-D shear wave elastography method using a 2-D row-column addressing array, demonstrating robust performance in both phantom and in vivo studies.

Lassa virus NP DEDDh 3'-5'exoribonuclease activity is required for optimal viral RNA replication and mutation control.

This study shows that Lassa virus NP ExoN is essential for viral RNA replication and mutation control, highlighting a new role for this protein beyond immune evasion.

Genome mining unveils a class of ribosomal peptides with two amino termini

The paper identifies a new class of ribosomal peptides, daptides, with two amino termini, discovered through genome mining and characterized experimentally.

High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

This paper introduces a new 3-D ultrasound imaging technique called FASTER that improves volume rate and usability compared to conventional methods.

SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.