Designed Anchoring Geometries Determine Lifetimes of Biotin-Streptavidin Bonds under Constant Load and Enable Ultra-Stable Coupling
S. Gruber, A. Loef, S. Sedlak, M. Benoit, H. Gaub, J. Lipfert
The paper investigates engineered streptavidin variants under constant force to determine how anchoring geometries affect biotin-streptavidin bond lifetimes, identifying a geometry that enables ultra-stable single molecule force spectroscopy.
bioRxiv · May 12, 2020Biophysics