A Conformational Transition of Von Willebrand Factor's D'D3 Domain Primes It For Multimerization
S. Gruber, A. Loef, A. Hausch, R. Joehr, T. Obser, G. Koenig, R. Schneppenheim, M. A. Brehm, M. Benoit, J. Lipfert
This study uses single-molecule force spectroscopy to show that a conformational change in VWF's DD3 domain, triggered by pH changes and stabilized by FVIII, primes it for multimerization.
bioRxiv · Nov 29, 2021 · PreprintBiophysics