Natural Occurring Non-Synonymous Single Nucleotide Polymorphisms in Integrase and RNase H Regulate Assembly and Autoprocessing of HIV-1
T. Imamichi, J. G. Bernbaum, S. Laverdure, J. Yang, Q. Chen, H. Highbarger, M. Hao, H. Sui, R. Dewar, W. Chang, H. C. Lane
This paper investigates the impact of 14 non-synonymous SNPs in HIV on viral fitness, finding that specific mutations in integrase and RNase H impair GagPol autoprocessing and replication.
Journal of Virology · Nov 9, 2021Peer-reviewedMicrobiology