Q. Chen

Metaplasia Enables Stomach Colonization by Fusobacterium animalis

This study shows that H. pylori-induced gastric metaplasia enables F. animalis colonization, which is associated with increased Gal-GalNAc and reduced acidity.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Use of optimized single-cell RNA flow cytometry protocol identifies monocytes as main producers of type I interferon in mouse syngeneic tumors

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

Placental extracellular vesicles from early-onset but not late-onset preeclampsia induce a pro-vasoconstrictive and anti-vasodilatory state in resistance arteries

This study shows that placental EVs from early-onset preeclampsia impair maternal vascular function, while those from late-onset preeclampsia have minimal effect.

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

Identification of the potassium binding site in serotonin transporter SERT

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

A Blueprint for Broadly Effective Bacteriophage Therapy Against Bacterial Infections

This paper develops broad-spectrum bacteriophage therapy cocktails effective against multiple bacterial strains and infections.

β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice

This study shows that β-glucan-induced trained immunity in mice enhances antibody levels after vaccination by improving antigen presentation and T-cell responses.

Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands

This study shows nutrient addition reduces plant diversity at local and larger scales equally, without causing biotic homogenization in global grasslands.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties

The paper identifies a small molecule, A1155463, that induces trained immunity in macrophages without being immunogenic, enhancing anti-tumor resistance in mice.

Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

This study identifies transcriptomic and immune features of gastric cancer peritoneal metastases, highlighting predictive markers and therapeutic targets in the tumor microenvironment.

Escherichia coli grown in cost-effective conical tubes produces more plasmid DNA

The paper compares plasmid yield from different bacterial growth tubes and finds that Oxford conical-polypropylene tubes produce 1.5-fold more plasmid DNA than other polypropylene tubes.

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

Single-Cell Transcriptomic Profiling Unveils Critical Metabolic Alterations and Signatures in Progression of Atherosclerosis

This study uses single-cell RNA sequencing to identify metabolic changes and gene signatures in atherosclerosis progression, revealing altered metabolic pathways and cell-cell interactions.

Environmental DNA from ethanol eluent of flowers reveals a widespread diversity in cowpea associated animal communities in Hainan Island

This study uses eDNA metabarcoding to analyze cowpea-associated animal communities in Hainan, identifying 62 species, mostly arthropods, and highlighting regional diversity and pesticide impacts.

The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

Postharvest partial dehydration of blueberries enhanced blueberry wine aroma via upregulating phenylalanine metabolism and terpene biosynthesis

This study shows that postharvest partial dehydration of blueberries increases phenylalanine-derived and terpene compounds, enhancing blueberry wine aroma through upregulated metabolic pathways.

Targeting ductal-endothelial crosstalk alleviate pancreatitis

This study shows that blocking integrin-5 signaling reduces acute pancreatitis severity by mitigating ductal-endothelial crosstalk disruption.

The mechanosensitive Pkd2 channel modulates the recruitment of myosin II and actin to the cytokinetic contractile ring

This study shows that the Pkd2 channel regulates myosin II and actin recruitment to the cytokinetic contractile ring in fission yeast, suggesting a calcium-dependent mechanism.

Aberrant non-canonical NF-kappaB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma

This study shows that aberrant non-canonical NF-kappaB signalling reprograms the epigenome to drive oncogenic transcriptomes in multiple myeloma by promoting super-enhancers and cis-regulatory interactions.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

The change of lymphocyte subsets and inflammatory cytokine in BK viruria

This study compares cytokine levels in urine and blood of kidney transplant recipients with and without BK viruria, finding higher inflammatory cytokines in BK-positive patients.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.