W. Chang

Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

The synergistic effects of plants and nitrogen on microbial hitchhiking

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex

This study determines the structure and function of the H2 protein in the vaccinia virus entry fusion complex, identifying key regions involved in membrane fusion and complex formation.

Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations

This study characterizes the vaccinia virus A28 protein through NMR and molecular dynamics simulations, identifying key residues for H2 binding and membrane fusion.

Drought and recovery in barley: key gene networks and retrotransposon response.

This study examines drought responses in barley varieties, identifying gene networks and retrotransposon dynamics under drought and recovery conditions.

m6A Demethylase FTO Stabilizes LINK-A to Exert Oncogenic Roles via MCM3-Mediated Cell Cycle Progression and HIF-1α Activation

This study shows FTO stabilizes LINK-A, promoting ESCC progression through MCM3-mediated cell cycle progression and HIF-1α activation.

Widespread distribution and evolution of poxviral entry-fusion complex proteins in giant viruses

This study identifies and analyzes the distribution and evolution of EFC protein homologs across poxviruses and other giant viruses in Nucleocytoviricota, revealing conserved structural features and suggesting an ancient origin for these proteins.

Comparing rapid rule-learning strategies in humans and monkeys

This study compares rule-learning strategies between humans and macaque monkeys in a card-sorting task, finding differences in speed and error patterns.

The C-terminal domain of RNase H and the C-terminus amino acid residue regulate virus release and autoprocessing of a defective HIV-1 possessing M50I and V151I changes in integrase

This study identifies the C-terminal domains of RNase H and integrase as regulators of virus release and autoprocessing in a defective HIV-1 variant with specific mutations.

Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease

The paper defines novel osteolineage gene sets using single-cell transcriptomics and identifies molecular defects in a CKD mouse model.

HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

FcRγ- NK cell induction by specific CMV and expansion by subclinical viral infections in rhesus macaques

This study identifies RhCMV-specific induction of FcRγ-deficient NK cells in rhesus macaques, with co-infections enhancing their frequency.

DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

FAM21 is critical for TLR2-CLEC4E-mediated dendritic cell function against Candida albicans

This study shows FAM21 is essential for dendritic cell function against Candida albicans by regulating TLR2/CLEC4E signaling and phagocytosis.

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

Rapid evolution of the functionally conserved gap gene giant in Drosophila

This study shows that essential developmental genes can undergo functional divergence while maintaining conserved developmental outcomes, challenging the idea that such genes are evolutionarily protected.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

Natural Occurring Non-Synonymous Single Nucleotide Polymorphisms in Integrase and RNase H Regulate Assembly and Autoprocessing of HIV-1

This paper investigates the impact of 14 non-synonymous SNPs in HIV on viral fitness, finding that specific mutations in integrase and RNase H impair GagPol autoprocessing and replication.

FBW7 couples structural integrity with functional output of primary cilia

The paper investigates how FBW7 regulates ciliary length and its impact on mesenchymal stem cell differentiation and bone architecture.

VC1 catalyzes a key step in the biosynthesis of vicine from GTP in faba bean

The paper identifies VC1 as the enzyme catalyzing vicine biosynthesis from GTP in faba bean and shows its role in vicine content regulation.

Population genetics of the highly polymorphic RPP8 gene family

The paper investigates the polymorphism of the RPP8 gene family in Arabidopsis, finding that balancing selection contributes to its high diversity despite low heterozygosity.

Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging

This study identifies imbalanced nucleocytoskeletal connections as a cause of polarity defects in progeria and aging, showing that rebalancing these connections can restore normal cell function.