MicrobiologybioRxiv
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300
D. A. Davis, H. Bulut, P. Shrestha…·R. Yarchoan
This study shows that SARS-CoV-2 main protease (Mpro) activity and dimerization are regulated by reversible glutathionylation of Cys300, offering a new target for antiviral agents.
DOI 10.1128/mbio.02094-21