Author

H. L. Malaby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Stumpff· 3 shared C. L. Fonseca· 2 shared C. Marquis· 2 shared A. Czechanski· 1 shared A. J. Bass· 1 shared A. Jones· 1 shared A. Nagaraja· 1 shared C. Byers· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

J. Stumpff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chromosomally unstable tumor cells specifically require KIF18A for proliferation

C. Marquis, C. L. Fonseca, K. A. Queen, L. Wood, S. E. Vandal, H. L. Malaby, J. E. Clayton, J. Stumpff

This study shows KIF18A is essential for proliferation of chromosomally unstable tumor cells but not near-diploid cells, with effects linked to centrosome fragmentation and mitotic defects.

bioRxiv · Jun 18, 2020Cell Biology

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

Y. Cohen-Sharir, J. M. McFarland, M. Abdusamad, C. Marquis, H. Tang, M. R. Ippolito, S. V. Bernhard, K. Laue, H. L. Malaby, A. Jones, M. Kazachkova, N. Lyons, A. Nagaraja, A. J. Bass, R. Beroukhim, , U. Ben-David

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

bioRxiv · Jun 18, 2020Cancer Biology

Mitotic chromosome alignment is required for proper nuclear envelope reassembly

C. L. Fonseca, H. L. Malaby, L. A. Sepaniac, W. Martin, C. Byers, A. Czechanski, D. Messinger, M. E. Tang, R. Ohi, L. G. Reinholdt, J. Stumpff

This study shows that mitotic chromosome alignment is necessary for correct nuclear envelope reassembly and cell proliferation, despite being dispensable for maintaining euploidy.

bioRxiv · Jun 11, 2018Cell Biology