H. Tang

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

The Unexpected Membrane Targeting of Marchantia Short PIN Auxin Exporters Illuminates Sequence Determinants and Evolutionary Significance

This study identifies the sequence determinant for PM localization in short PINs and explains the evolutionary shift from PM- to ER-localized PINs in land plants.

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

The heterogeneity and effect of diabetes and hypertension on spectral characteristics of vasomotion

This study examines how diabetes and hypertension affect vasomotion spectral characteristics at specific acupoints using Laser Doppler Flowmetry and signal analysis techniques.

A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

This paper develops a humanized immune stroma PDX model to better reflect therapeutic resistance and patient response to immunotherapies.

Divergence of TORC1-mediated Stress Response Leads to Novel Acquired Stress Resistance in a Pathogenic Yeast

The paper identifies how phosphate starvation induces oxidative stress resistance in C. glabrata but not S. cerevisiae through rewired TORC1 signaling and TF networks.

Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of Helicobacter pylori Morphology, Cell Wall Permeability, and Antimicobial Susceptibilities

This study investigates the roles of LPS glycosyltransferases in H. pylori morphology, cell wall permeability, and antimicrobial susceptibility, finding that their deletion alters morphology and increases susceptibility to certain antimicrobials.

Omicron Spike Protein Is Vulnerable to Reduction

This study shows that Omicron SARS-CoV-2 spike proteins are more susceptible to reduction due to mutations in the receptor binding module, which affects their stability and binding activity.

MSP1 encodes an essential RNA-binding PPR factor required for nad1 maturation and complex I biogenesis in Arabidopsis mitochondria

This study identifies MSP1 as an essential PPR protein required for nad1 RNA processing and complex I biogenesis in Arabidopsis mitochondria, leading to seed abortion in its loss-of-function mutants.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT

The paper identifies shared minor histocompatibility antigens (mHAs) that could enhance graft versus leukemia (GvL) effects while minimizing graft versus host disease (GvHD) in allogeneic hematopoietic cell transplants.

Creating a thermostable beta-glucuronidase switch for homogeneous immunoassay by disruption of conserved salt bridges at diagonal interfaces

This paper develops a thermostable beta-glucuronidase switch by disrupting salt bridges, enhancing signal-to-background ratio for immunosensors.

Enhancement of Cell Adhesion by Anaplasma phagocytophilum Nucleolin-interacting Protein AFAP

This study identifies AFAP as a bacterial protein that enhances cell adhesion by interacting with host nucleolin, providing insights into the mechanism of A. phagocytophilum-induced cell adhesion in HGA.

Divergence of trafficking and polarity mechanisms for PIN auxin transporters during land plant evolution

This study investigates the divergence of PIN auxin transporter trafficking and polarity mechanisms across land plants, revealing differences between bryophytes and flowering plants.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

Vitamin D receptor cistrome-transcriptome analyses establishes quantitatively distinct receptor genomic interactions in African American prostate cancer regulated by BAZ1A

The paper analyzes VDR genomic interactions in African American prostate cancer cells and identifies BAZ1A as a regulator of VDR-dependent transcriptional responses.

Mapping SARS-CoV-2 antigenic relationships and serological responses

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

SAMase of bacteriophage T3 inactivates E. coli methionine S-adenosyltransferase by forming hetero-polymers

This paper shows that bacteriophage T3's SAMase degrades SAM and inhibits E. coli's MAT by forming hetero-polymers, leading to metabolic disruption.

A cold shock protein from a thermophile bacterium promotes the high-temperature growth of bacteria and fungi through binding to diverse RNA species

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

This study identifies potential bacterial transmission between hospitalized HCT patients through metagenomic sequencing, finding shared strains in some pairs but not widespread colonization.