R. Ohi

SETD2 safeguards the genome against isochromosome formation

This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.

β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma

This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15

This study investigates how Kif15 reinforces k-fiber bundles in the mitotic spindle through microtubule crosslinking, preventing chromosome segregation errors.

Precise tuning of cortical contractility regulates cell shape during cytokinesis

This study shows that balancing MII paralogs fine-tunes polar cortex tension to maintain cell shape during cytokinesis.

Kinesin-Binding Protein (KBP) buffers the activity of Kif18A and Kif15 in mitosis to ensure accurate chromosome segregation

This study identifies KBP as a regulator of KIF18A and KIF15 during mitosis, showing it buffers their activity to ensure accurate chromosome segregation.

Mitotic chromosome alignment is required for proper nuclear envelope reassembly

This study shows that mitotic chromosome alignment is necessary for correct nuclear envelope reassembly and cell proliferation, despite being dispensable for maintaining euploidy.

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

This study shows HSET forms MT asters using soluble tubulin, not pre-formed MTs, and proposes a model where tubulin availability governs aster versus bundle formation.