Radiosynthesis and Preclinical Evaluation of Ga-NOTA-Folate for PET Imaging of Folate Receptor βPositive Macrophages
O. Moisio, S. Palani, J. Virta, P. Elo, H. Liljenback, T. Tolvanen, M. Kakela, M. G. Miner, E. Atencio Herre, P. Marjamaki, T. Ord, M. Heinaniemi, M. Kaikkonen-Maatta, F. Zhang, M. Srinivasarao, , A. Roivainen
This paper develops and evaluates [68Ga]Ga-NOTA-folate (68Ga-FOL) as a PET tracer for imaging FR-{beta}-positive macrophages in atherosclerosis, showing high affinity and specificity.
bioRxiv · May 18, 2020Biochemistry