Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer
E. Visser, M. Donaldson Collier, J. Siefert, M. Konstantinidou, S. Paul, J. Berkhout, J. Virta, B. Somsen, P. Cossar, G. Miley, L. Luzietti, L. Young, D. Vareslija, L. Buluwela, S. Ali, , L. Brunsveld
This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.
bioRxiv · Apr 25, 2024 · PreprintCancer Biology