H. Link

The SPFH complex HflK-HflC regulates aerobic respiration in bacteria

This study identifies the HflK-HflC complex as essential for aerobic respiration in E. coli by regulating IspG abundance and ubiquinone levels.

(p)ppGpp-mediated GTP homeostasis ensures the survival and antibiotic tolerance of Staphylococcus aureus during starvation by preserving the proton motive force

Metabolic rewiring compensates for the loss of glutamate and aspartate biosynthesis in Bacillus subtilis

This study identifies a non-canonical fumarate-based ammonium assimilation pathway in B. subtilis that compensates for glutamate and aspartate biosynthesis defects.

Purine nucleotide limitation undermines antibiotic action in clinical Escherichia coli

This study identifies purine nucleotide limitation as a mechanism conferring antibiotic resistance in E. coli by reducing ATP supply and upregulating the purine nucleoside transporter PunC.

Helicobacter pylori modulates heptose metabolite biosynthesis and heptose-dependent innate immune host cell activation by multiple mechanisms

This study investigates how Helicobacter pylori regulates heptose metabolite biosynthesis and its impact on innate immune activation in human cells.

Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry

The paper systematically analyzes in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry, identifying extensive modifications and explaining 49% of them using a network approach.

Horizontal transfer of bacteriocin biosynthesis genes requires metabolic adaptation to improve compound production and cellular fitness

This study shows that transferring bacteriocin biosynthesis genes between Staphylococcus aureus strains requires metabolic adaptation to enhance compound production and cellular fitness.

How to deal with toxic amino acids: the bipartite AzlCD complex exports histidine in Bacillus subtilis

The paper identifies AzlCD as a histidine exporter in Bacillus subtilis that confers resistance to toxic histidine levels by increasing extracellular histidine concentration.

Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

This study investigates spatial alanine metabolism in E. coli biofilms, revealing distinct metabolic roles in different regions that influence colony growth and morphology.

Dissecting the impact of metabolic environment on three common cancer cell phenotypes

This study examines how different metabolic environments affect three cancer cell phenotypes: drug survival, migration, and lactate overflow, revealing quantitative relationships between metabolism and cell behavior.