Author

A. Peschel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 8 Research Focus:host-pathogen & immune response· 7 Assay:proteomics· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3

Frequent Co-Authors

C. J. Slavetinsky· 4 shared A. M. A. Elsherbini· 3 shared R. van Dalen· 3 shared A. Kengmo Tchoupa· 2 shared A. Walter· 2 shared B. Krismer· 2 shared C. M. Ernst· 2 shared C. Mayer· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMicrobiology

C. J. Slavetinsky

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10 papers

Recent·Most cited

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

C. R. Beck, J. Krusche, A. Notaro, A. Walter, L. Krankel, A. Vollert, R. Stemmler, J. Wittmann, M. Schaller, C. J. Slavetinsky, C. Mayer, C. De Castro, A. Peschel

This study identifies a WTA glycosyltransferase in S. epidermidis that modifies WTA with glucose, altering phage susceptibility and enabling horizontal gene transfer among CoNS species.

bioRxiv · Jul 27, 2023Microbiology

The capsular polysaccharide obstructs wall teichoic acid functions in Staphylococcus aureus

E. Lehmann, R. van Dalen, L. Gritsch, C. J. Slavetinsky, N. Korn, C. Rohmer, D. Krause, A. Peschel, C. Weidenmaier, C. Wolz

The paper investigates how capsular polysaccharide (CP) in Staphylococcus aureus affects wall teichoic acid (WTA) functions, finding that CP interferes with WTA-mediated processes like phage binding and adhesion but enhances virulence.

bioRxiv · Jul 26, 2023 · PreprintMicrobiology

Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus

A. Kengmo Tchoupa, A. M. A. Elsherbini, X. Fu, O. Ghaneme, L. Seibert, M. A. Boecker, M. Lebtig, J. Camus, S. Papadopoulos Lambidis, B. Schittek, D. Kretschmer, M. Laemmerhofer, A. Peschel

This study identifies Lip2 as a Staphylococcus aureus lipase that detoxifies antimicrobial fatty acids via esterification with cholesterol, revealing its role in skin colonization resistance.

bioRxiv · May 15, 2023Microbiology

Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus

J. Yang, J. Z. Bowring, J. Krusche, B. S. Bejder, S. F. Silva, M. S. Bojer, T. Grunert, A. Peschel, H. Ingmer

The paper shows that quorum sensing in Staphylococcus aureus controls phage susceptibility by modulating receptor structures, and that cross-species communication with non-aureus staphylococci can protect S. aureus from phage infection.

bioRxiv · Apr 3, 2023 · PreprintMicrobiology

Targeting of the human nasal microbiota by secretory IgA antibodies

R. van Dalen, A. M. A. Elsherbini, M. Harms, S. Alber, R. Stemmler, A. Peschel

This study identifies bacterial genera and species targeted by sIgA in the nasal microbiome using IgA-seq and sIgA deposition experiments, showing individual variation and epitope-independent interactions with S. aureus.

bioRxiv · Aug 31, 2022 · PreprintMicrobiology

Horizontal transfer of bacteriocin biosynthesis genes requires metabolic adaptation to improve compound production and cellular fitness

S. Krauss, T. A. Harbig, J. Rapp, T. Schäfle, M. Franz-Wachtel, L. Reetz, A. M. A. Elsherbini, B. Macek, S. Grond, H. Link, K. Nieselt, B. Krismer, A. Peschel, S. Heilbronner

This study shows that transferring bacteriocin biosynthesis genes between Staphylococcus aureus strains requires metabolic adaptation to enhance compound production and cellular fitness.

bioRxiv · Jul 28, 2022Microbiology

PplT domain proteins - ubiquitous potential prokaryotic phospholipid translocases

J. N. Hauser, A. Kengmo Tchoupa, S. Zabel, K. Nieselt, C. M. Ernst, C. J. Slavetinsky, A. Peschel

The paper identifies PplT domain proteins in bacteria and archaea as potential phospholipid translocases, showing their role in membrane lipid metabolism and growth.

bioRxiv · Mar 11, 2022 · PreprintMicrobiology

Sensitizing Staphylococcus aureus to antibacterial host defense by decoding and blocking the lipid flippase MprF

C. J. Slavetinsky, J. N. Hauser, C. Gekeler, J. Slavetinsky, A. Geyer, A. Kraus, D. Heilingbrunner, S. Wagner, M. Tesar, B. Krismer, S. Kuhn, C. M. Ernst, A. Peschel

This study develops MprF-targeting monoclonal antibodies that block the lipid flippase MprF, increasing MRSA susceptibility to antimicrobial peptides and antibiotics.

bioRxiv · Nov 12, 2020Microbiology

The impact of Staphylococcus aureus cell wall glycosylation on langerin recognition and Langerhans cell activation

A. Hendriks, R. van Dalen, S. Ali, D. Gerlach, G. A. van der Marel, F. F. Fuchsberger, P. Aerts, C. J. C. de Haas, A. Peschel, C. Rademacher, J. van Strijp, J. D. Codee, N. M. van Sorge

This study investigates how different glycosylation patterns on Staphylococcus aureus cell walls affect langerin recognition and Langerhans cell activation, finding that β-GlcNAc is sufficient for langerin binding regardless of its position on WTA.

bioRxiv · Nov 6, 2020Microbiology

Phosphoglycerol-type wall- and lipoteichoic acids are enantiomeric polymers differentially cleaved by the stereospecific glycerophosphodiesterase GlpQ

A. Walter, S. Unsleber, J. Rismondo, A. M. Jorge, A. Peschel, A. Grundling, C. Mayer

This study demonstrates that WTA and LTA are enantiomeric polymers differentially cleaved by GlpQ, revealing stereochemical differences in their glycerol phosphate moieties.

bioRxiv · Jan 8, 2020Microbiology