Author

H. Lockstone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

B. Wright· 2 shared A. Biroccio· 1 shared A. Harris· 1 shared A. Londono· 1 shared A. Miar· 1 shared D. Greaves· 1 shared E. McNeill· 1 shared E. Puig Lombardi· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

B. Wright

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2 papers

Recent·Most cited

Ly6Chi monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment

G. Purvis, E. McNeill, B. Wright, S. Revale, H. Lockstone, K. Channon, D. Greaves

The paper shows Ly6Chi monocytes undergo metabolic reprogramming during inflammation, enabling macrophage lineage commitment through oxidative phosphorylation.

bioRxiv · Nov 15, 2021 · PreprintImmunology

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

T. Reislander, E. Puig Lombardi, F. J. Groelly, A. Miar, M. Porru, B. Wright, H. Lockstone, A. Biroccio, A. Harris, A. Londono, M. Tarsounas

This study shows that BRCA2 loss in cancer cells triggers innate immune responses, which are enhanced by PARP inhibitors, suggesting a mechanism for their therapeutic effect.

bioRxiv · Dec 10, 2018Cancer Biology