Author

D. Greaves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

G. Purvis· 2 shared K. Channon· 2 shared A. Ali· 1 shared A. Deik· 1 shared A. Farsidjani· 1 shared A. Muir· 1 shared A. Van Dam· 1 shared B. T. Do· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPathology

G. Purvis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

G. Purvis, M. Collino, A. Van Dam, G. Einaudi, Y. Ng, M. Shanmuganathan, S. Patel, C. Thiemermann, K. Channon, D. Greaves

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

bioRxiv · Oct 9, 2023Pathology

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Ly6Chi monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment

G. Purvis, E. McNeill, B. Wright, S. Revale, H. Lockstone, K. Channon, D. Greaves

The paper shows Ly6Chi monocytes undergo metabolic reprogramming during inflammation, enabling macrophage lineage commitment through oxidative phosphorylation.

bioRxiv · Nov 15, 2021 · PreprintImmunology