Author

H. Luesch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ATAC-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Q.-Y. Chen· 3 shared K. R. Atanasova· 2 shared R. Ratnayake· 2 shared A. M. G. K. Athapaththu· 1 shared C. M. Perkins· 1 shared C.-W. Wu· 1 shared E. Abraham· 1 shared J. Jiang· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPharmacology & Toxicology

Q.-Y. Chen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response

E. Abraham, A. M. G. K. Athapaththu, K. R. Atanasova, Q.-Y. Chen, T. J. Corcoran, J. Piloto, C.-W. Wu, R. Ratnayake, H. Luesch, K. P. Choe

bioRxiv · Feb 15, 2024 · PreprintPharmacology & Toxicology

Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids

K. R. Atanasova, C. M. Perkins, R. Ratnayake, J. Jiang, Q.-Y. Chen, T. D. Schmittgen, H. Luesch

The paper screens epigenetic small molecules to inhibit and reverse acinar ductal metaplasia in mouse pancreatic organoids, identifying several effective compounds with improved activity over TSA.

bioRxiv · Nov 27, 2023 · PreprintCancer Biology

Nuclear quality control of non-imported secretory proteins attenuates proteostasis decline in the cytosol

P. Banik, J. Kamps, Q.-Y. Chen, H. Luesch, K. F. Winklhofer, J. Tatzelt

The paper identifies a nuclear quality control pathway that degrades mislocalized secretory proteins to prevent cytosolic proteostasis decline.

bioRxiv · Jun 27, 2023 · PreprintCell Biology