K. F. Winklhofer

This study shows that linear ubiquitination at damaged lysosomes activates NF-κB and promotes cell survival through lysophagy.

This paper identifies a novel PEX14/PEX5 interface involved in peroxisomal protein import and receptor recycling through biochemical and structural analysis.

The paper identifies a nuclear quality control pathway that degrades mislocalized secretory proteins to prevent cytosolic proteostasis decline.

This study identifies a NF-κB-independent role of NEMO in proteostasis by promoting aggrephagy through co-condensation with p62.

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.