Author

H. Onaka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. A. Vinogradov· 3 shared H. Suga· 3 shared S. Asamizu· 3 shared Y. Goto· 3 shared M. Shimomura· 2 shared J. S. Chang· 1 shared M. Kato· 1 shared N. Kano· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

A. A. Vinogradov

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Author profile →

5 papers

Recent·Most cited

Redox-active compound generated by bacterial crosstalk induces hypha branching in Streptomyces species

M. Kato, S. Asamizu, H. Onaka

This paper identifies pyrogallol, a redox-active compound from bacterial crosstalk, as an inducer of hyphae branching in Streptomyces species via reactive oxygen species.

bioRxiv · Jan 12, 2023 · PreprintMicrobiology

Regulation of multidrug efflux pumps by TetR family transcriptional repressor negatively affects secondary metabolism in Streptomyces coelicolor A3(2)

Y. Lei, S. Asamizu, T. Ishizuka, H. Onaka

This study identifies TFR-ABC transporter gene sets in Streptomyces coelicolor that regulate secondary metabolism and antibiotic resistance by repressing efflux pump expression.

bioRxiv · Nov 11, 2022 · PreprintMicrobiology

Accurate models of substrate preferences of post-translational modification enzymes from a combination of mRNA display and deep learning

A. A. Vinogradov, J. S. Chang, H. Onaka, Y. Goto, H. Suga

The paper develops a platform combining mRNA display and deep learning to accurately model substrate preferences of PTM enzymes, showing high accuracy and complexity in enzyme specificity.

bioRxiv · Feb 14, 2022Biochemistry

Promiscuous enzymes cooperate at the substrate level en route to lactazole A

A. A. Vinogradov, M. Shimomura, N. Kano, Y. Goto, H. Onaka, H. Suga

This study investigates the biosynthesis of lactazole A, revealing dynamic enzyme cooperation and kinetic control in thiopeptide assembly using an in vitro system.

bioRxiv · May 12, 2020Biochemistry

Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides

A. A. Vinogradov, M. Shimomura, Y. Goto, T. Ozaki, S. Asamizu, Y. Sugai, H. Suga, H. Onaka

This paper develops a platform for in vitro biosynthesis of lactazole A, enabling the creation of diverse thiopeptide analogs with modified structures.

bioRxiv · Oct 16, 2019 · PreprintBiochemistry