Author

A. A. Vinogradov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

H. Onaka· 3 shared H. Suga· 3 shared Y. Goto· 3 shared M. Shimomura· 2 shared J. S. Chang· 1 shared N. Kano· 1 shared S. Asamizu· 1 shared T. Ozaki· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

H. Onaka

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3 papers

Recent·Most cited

BiochemistrybioRxivFeb 14, 2022

Accurate models of substrate preferences of post-translational modification enzymes from a combination of mRNA display and deep learning

A. A. Vinogradov, J. S. Chang, H. Onaka…·H. Suga

The paper develops a platform combining mRNA display and deep learning to accurately model substrate preferences of PTM enzymes, showing high accuracy and complexity in enzyme specificity.

DOI 10.1021/acscentsci.2c00223

proteomicsdeep learning

𝕏 PostBluesky

BiochemistrybioRxivMay 12, 2020

Promiscuous enzymes cooperate at the substrate level en route to lactazole A

A. A. Vinogradov, M. Shimomura, N. Kano…·H. Suga

This study investigates the biosynthesis of lactazole A, revealing dynamic enzyme cooperation and kinetic control in thiopeptide assembly using an in vitro system.

DOI 10.1021/jacs.0c05541

experimental assaysynaptic & neural circuits

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 16, 2019

Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides

A. A. Vinogradov, M. Shimomura, Y. Goto…·H. Onaka

This paper develops a platform for in vitro biosynthesis of lactazole A, enabling the creation of diverse thiopeptide analogs with modified structures.

DOI 10.1101/807206

experimental assaydrug response / drug discovery

𝕏 PostBluesky