The Achromobacter Type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes
K. Turton, H. Parks, P. Zarodkiewicz, M. A. Hamad, R. Dwane, G. Parau, R. J. Ingram, R. C. Coll, C. E. Bryant, M. A. Valvano
This study shows Achromobacter uses its Type 3 Secretion System to trigger pyroptosis via NLRC4 and NLRP3 inflammasomes, causing immunopathology in macrophages and mice.
Cell Reports · Aug 1, 2023Peer-reviewedMicrobiology