Author

C. E. Bryant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biophysics· 2 Microbiology· 2 Bioengineering· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 6 Research Focus:cell signaling & trafficking· 5 Organism:mouse· 5 Organism:human· 3 Assay:imaging· 3 Assay:proteomics· 3 Organism:chicken / avian· 2

Frequent Co-Authors

B. J. Ferguson· 2 shared D. R. Rodrigues· 2 shared L. Hopkins· 2 shared M. Oliveira· 2 shared R. Guabiraba· 2 shared A. C. Borgeaud· 1 shared A. Carnicer-Lombarte· 1 shared A. F. Baptista· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

B. J. Ferguson

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations

L. G. Welch, J. Estranero, P. Tourlomousis, R. C. R. Wootton, V. Radu, C. Gonzalez-Fernandez|, T. J. Puchtler, C. M. Murzeau, N. M. G. Dieckmann, A. Shibahara, B. W. Longbottom, C. E. Bryant, E. L. Talbot

This paper introduces an automated optical electrowetting-on-dielectric platform for performing complex single-cell assays in parallel, enabling direct functional analysis of individual cells.

bioRxiv · Mar 19, 2024Cell Biology

An ovine model for investigation of the microenvironment of the male mammary gland

B. P. Davies, R. C. Crew, A. L. K. Cochrane, K. Davies, A. F. Baptista, S. Jeckel, I. McCrone, Y. Niu, B. W. Strugnell, K. Waine, A. L. Fowden, C. E. Bryant, J. W. Wills, D. A. Giussani, K. Hughes

This study evaluates the male ovine mammary gland microenvironment, comparing intact and neutered males, and demonstrates its utility as a model for male breast biology.

bioRxiv · Dec 17, 2023Pathology

Mechanisms of type I interferon production by chicken TLR21

R. Guabiraba, D. R. Rodrigues, P. T. Manna, M. Chollot, V. Saint-Martin, S. Trapp, M. Oliveira, C. E. Bryant, B. J. Ferguson

This study investigates how chicken TLR21 triggers type I interferon production in macrophages, revealing conserved signaling pathways with mammalian TLR9.

bioRxiv · Sep 20, 2023Immunology

The Achromobacter Type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

K. Turton, H. Parks, P. Zarodkiewicz, M. A. Hamad, R. Dwane, G. Parau, R. J. Ingram, R. C. Coll, C. E. Bryant, M. A. Valvano

This study shows Achromobacter uses its Type 3 Secretion System to trigger pyroptosis via NLRC4 and NLRP3 inflammasomes, causing immunopathology in macrophages and mice.

Cell Reports · Aug 1, 2023Peer-reviewedMicrobiology

Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen Cryptococcus neoformans.

C. U. Onyishi, G. E. Desanti, A. L. Wilkinson, G. Fejer, O. D. Christophe, C. E. Bryant, S. Mukhopadhyay, S. Gordon, R. C. May

This study identifies MSR1 as a key receptor for nonopsonic phagocytosis of Cryptococcus neoformans and shows TLR4/MSR1 crosstalk in this process.

bioRxiv · Jan 30, 2023 · PreprintMicrobiology

Foreign body reaction is triggered in vivo by cellular mechanosensing of implants stiffer than host tissue

A. Carnicer-Lombarte, D. G. Barone, I. B. Dimov, R. S. Hamilton, M. Prater, X. X. Zhao, A. L. Rutz, G. G. Malliaras, S. P. Lacour, C. E. Bryant, J. W. Fawcett, K. Franze

The paper shows that implants stiffer than host tissue trigger a foreign body reaction via mechanosensing, and soft coatings reduce inflammation and fibrosis.

bioRxiv · Dec 28, 2022 · PreprintBioengineering

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

Y. Liu, H. Zhai, H. Alemayehu, J. Boulanger, L. J. Hopkins, A. C. Borgeaud, C. Heroven, J. D. Howe, K. E. Leigh, C. E. Bryant, Y. Modis

The paper uses cryo-electron tomography to reveal the ultrastructure of ASC specks and gasdermin D pores in NLRP3-activated cells.

bioRxiv · Sep 20, 2021Immunology

Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infections

Z. Digby, J. Rooney, J. P. Boyle, B. B. Verdugo, R. Pickering, S. J. Webster, T. Monie, L. Hopkins, N. Kayagaki, G. Salvesen, S. Warming, L. Weinert, C. E. Bryant

The paper investigates evolutionary changes in inflammasome pathways in carnivores, finding reduced immune sensing that may facilitate zoonotic pathogen carriage.

bioRxiv · Dec 7, 2020 · PreprintImmunology

Chicken cGAS senses fowlpox virus infection and regulates macrophage effector function

M. Oliveira, D. R. Rodrigues, V. Guillory, E. Kut, E. S. Giotis, M. A. Skinner, R. Guabiraba, C. E. Bryant, B. J. Ferguson

This study shows that chicken cGAS detects fowlpox virus DNA, triggering type-I interferon production and regulating macrophage effector functions like MHC-II expression.

bioRxiv · Oct 1, 2020Immunology

Single-molecule light-sheet microscopy with local nanopipette delivery

B. Li, A. Ponjavic, W.-H. Chen, L. Hopkins, C. Hughes, Y. Ye, C. E. Bryant, D. Klenerman

This paper introduces ldSPIM, a method combining light sheet microscopy with nanopipette delivery to precisely deliver single molecules to cells and image their effects in real-time.

bioRxiv · Sep 25, 2020Biophysics

Criticality of plasma membrane lipids reflects activation state of macrophage cells

E. Cammarota, C. Soriani, R. Taub, F. Morgan, J. Sakai, S. Veatch, C. E. Bryant, P. Cicuta

The paper examines how macrophage plasma membrane lipid composition changes in response to inflammatory stimuli, showing that proximity to a critical point affects membrane protein activity.

bioRxiv · Jun 23, 2019Biophysics