BiochemistrybioRxiv
A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
M. Cao, A. M. Day, M. Galler…·E. A. Veal
This paper shows that a Peroxiredoxin-P38 MAPK fusion protein hyperactivates P38 MAPK in yeast and human cells without requiring H2O2-sensing cysteines, suggesting a novel scaffold-based signaling mechanism.