Author

Hao Ruan

Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

Edward A. LemkeiD· 3 shared Martin GirardiD· 2 shared Rodrigo F. DillenburgiD· 2 shared Achim H. SchwermanniD· 1 shared Alam Ahmad HidayatiD· 1 shared Anlong LiiD· 1 shared Carla SchmidtiD· 1 shared Dorothee DormanniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

Edward A. LemkeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Phosphorylation-Induced Micellization switch in the low complexity domain of TDP-43

Rodrigo F. Dillenburg, Lopatina Anastasia, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Hesselbarth, Frank Schafer-Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas S. Stelzl, , Edward A. Lemke

This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.

Advanced Science · Jul 28, 2026Peer-reviewedBiophysics

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores

Miao Yu, Maziar Heidari, Karen Palacio‐Rodríguez, Hao Ruan, Sara Mingu, Alam Ahmad Hidayat, Mathis Bode, Mateusz Sikora, Gerhard Hummer, Edward A. Lemke

The paper shows FG-NUPs in live cells exhibit liquid-like mobility, while in vitro they transition to solid, with O-GlcNAcylation and importin-β maintaining the dynamic FG network's liquidity.

bioRxiv · Dec 11, 2025 · PreprintBiophysics

Differential conformational expansion of Nup98-HOXA9 oncoprotein in micro- and macrophases

Hao Ruan, Rodrigo F. Dillenburg, Sina Wittmann, Martin Girard, Edward A. Lemke

This study examines the conformational changes of Nup98-HOXA9's FG domain across different assembly states, revealing micelle-like structures and dynamic transitions during condensate formation.

bioRxiv · May 21, 2025 · PreprintBiophysics

Sky islands of Southwest China. II: Unraveling hidden species diversity of talpid moles using phylogenomics and skull-based deep learning

Kai He, Anlong Li, Quentin Martinez, Xiaoyun Wang, Zhongzheng Chen, Shui-Wang He, Sining Xie, Zeling Zeng, Kunhui Wang, Ziqi Ye, Hao Ruan, Shiyun Liu, Qiuqin Lu, Xiaoyun Zheng, Jiayi Luo, , Kevin L. Campbell

This study uses phylogenomics and deep learning to identify hidden species diversity in talpid moles from Southwest China's sky islands, revealing previously unrecognized species.

bioRxiv · Mar 6, 2025 · PreprintZoology