Gerhard Hummer

This study determines the structure of DFCP1 and shows it forms a barrier that concentrates PI3P for lysosomal repair.

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

The paper elucidates the structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III through a combination of biochemical and structural methods.

This study identifies Atg1-mediated phosphorylation of Atg2 as a mechanism to activate lipid transfer during autophagosome biogenesis.

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

This study uses in situ structural biology to reveal the molecular organization of chromatin at the nuclear periphery in human cells.

This study identifies Arc as critical for packaging tau into extracellular vesicles, facilitating its release and intercellular transmission in Alzheimer's disease.

This paper develops a method to tune nanopore permeability using chemically modified alpha-hemolysin in synthetic cells.

The paper evaluates how specific PTMs affect tau protein aggregation using HCG and atomistic MD simulations, showing their impact on structural properties and aggregation behavior.

This study shows that disordered protein sequences encode characteristic small molecule binding pathways, identified through molecular dynamics simulations and machine learning.

This study uses cryo-electron tomography to show vault particles associate with ER and nuclear envelope membranes and enclose ribosomes in Dictyostelium discoideum.

The paper determines the structure of tafazzin and shows coenzyme A is bound to it, revealing a transacylation mechanism and molecular basis for Barth syndrome.

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

The paper shows FG-NUPs in live cells exhibit liquid-like mobility, while in vitro they transition to solid, with O-GlcNAcylation and importin-β maintaining the dynamic FG network's liquidity.

This paper introduces a Markov State Model to describe small molecule interactions with disordered proteins, identifying dynamic binding paths and druggable regions.

This study identifies the mechanism of ATG2A-mediated lipid transport in autophagy, revealing N-terminal helices as gates that regulate lipid transfer efficiency.

The paper identifies in situ structures of gap junctions in C. elegans using cryo-electron tomography and sub-tomogram averaging, revealing a cytosolic cap formed by the stomatin UNC-1 protein.

cryoTIGER uses deep learning to generate intermediate tilt images in cryo-electron tomography, improving 3D reconstruction and structural recovery.

The paper uses AlphaFold to model polyubiquitin complexes and covalently linked proteins by introducing correlated mutations and covalent linkers to improve structural predictions.

This paper uses AI-guided simulations to study STIM1 TM-helix dimerization, revealing three coexisting configurations and reconciling conflicting experimental results.

This study uses cryo-EM and molecular dynamics simulations to reveal structural flexibility in the human vault protein, identifying conformational states and dynamic assembly mechanisms.

This study identifies SND3 as a novel membrane insertase in the fungal SND pathway and presents its structure and mechanism for inserting multipass integral membrane proteins.

The paper investigates the role of mechanical forces in mitochondrial inner membrane extrusion and apoptotic pore growth using CLOSE microscopy.

The paper presents a fragment-based approach to improve LIR prediction using AlphaFold2, showing that fragment length and phosphomimetic mutations affect interaction predictions.

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

The paper presents structural snapshots of the CODH/ACS complex in CO2 fixation, revealing conformational changes and reaction mechanisms for acetyl-CoA synthesis.

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.