APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids
Haohui Fang, Xiangyu Liao, C. Korin Bullen, Ruoyan Pu, Hu Wang, Juliana Condoleo, Sueanne Cheat, Xueyi Chen, Yanjun Zhang, Sonya Zhang, Da Huo, Kadia Lissit, Alina Yang, Kateri Jarvis, Stewart Neifert, , Jinchong Xu
This study shows that APOE genotype affects neurovascular vulnerability in human forebrain organoids under viral stress, with APOE2/2 and APOE4/4 showing distinct inflammatory and vascular responses.
bioRxiv · May 8, 2025 · PreprintNeuroscience