Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU model
Kinjal Desai, Anna Tymofyeyeva, Margaret M. Javier, Nataliia Svergun, Vincent Chen Ye, Garrett Bullivant, Jannine Forst, Matthaeus A. Ware, Michelle M. Kushida, Lilian Lee, Chunying Yu, Heather Whetstone, Ryan J. Ward, Biren M. Dave, Ahmed M. Aman, Peter B. Dirks
This study develops a mouse model of pediatric gliomas and identifies BRAF and MAPK signaling as critical drivers of tumor progression and therapeutic resistance.
bioRxiv · Feb 23, 2026 · PreprintCancer Biology